Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression.

نویسندگان

  • P K Peterson
  • G Gekker
  • M Bornemann
  • D Chatterjee
  • C C Chao
چکیده

Mycobacterium tuberculosis accelerates the progression of human immunodeficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 expression in U1 cells stimulated with mycobacterial lipoarabinomannans, support the rationale behind conducting controlled trials of this immunodeficiency agent with patients dually infected with HIV-1 and M. tuberculosis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 39 12  شماره 

صفحات  -

تاریخ انتشار 1995